Breaking News
MMATECH is proud to announce that her lecture was chosen to be presented in the 42nd Annual conference of orthopedics (IOA) in Tel Aviv, Israel, on 25 January 2023.
The lecture will present a special case of a patient who had a genetic disease in the hip, was operated 10 years ago receiving a MOM hip implant and needed a revision operation due to blood poisoning. The patient received a new MP-1 Implant (MMATECH) with great success.
We will be happy to see you attending our talk.
25 January, 2023 (11:57 am)
Implanting MP-1 Liner in THR MoM Revision Surgery – Special Case report
Alisa Buchman1, Simha Sibony2, Eric Oliver3, Daniel Levin4
1R&D, MMATECH Ltd., Israel
2Regulation, MMATECH Ltd., Israel
3BD, MMATECH, Israel
4Orthopedics, Rambam hospital RMC, Israel
August 2022
ISTA’s 33rd Annual Congress, 30th of August to 3rd of September 2022 at the Hyatt Regency Resort Hotel in Maui, Hawaii.
MMATECH Ltd. is proud to announce that two of its lectures were chosen to be presented at the ISTA conf. in Hawaii, 2022.
1 – In Session: Wear/damage problems & solutions
On 1st September 2022 at 4:22 PM
James Burn from NZ will present the results of 97 clinical surgeries of THR with MP-1 conducted by him.
Polyimide (MP-1) as a Bearing in Total Hip Arthroplasty (THR): First Ever Use and Clinical Study Results.
James Burn
2 – Session: Other joints (Trauma)
On 1st September 2022 at 9:27 AM
Alisa Buchman from MMATECH Israel will present the R&D results of nonmetal MP-1 trauma devices
Non-Metal Trauma Orthopedic Implants Using MP-1 Game-Changing Material
Alisa Buchman; Simha Sibony; Amir Oron
January 2022
Private surgery with MP-1 acetabular hip liner in February 2022
A woman from the Czech Republic contacted MMATECH in 2021 saying:
I need a revision operation of DePuy ASR XL. I am 40 years old and after not too well done previous surgery I have pelvis bones in bad condition. That’s the reason I would like to have a revision done with MP-1 material to have a better chance of longer prosthesis life.
I read about your implant and also I found http://balticimplants.eu/ offer implants with MP-1.
I got my test results for metals from endoprosthesis in the blood and it’s really high. I should not postpone surgery too long. But I do not want to lose the possibility of using MP-1, especially when I have been waiting so long and now it seems to be really possible. Thank you so much!!
So, luckily after achieving the AMAR’ Dr. Daniel Levin will operate the lady on 10 February 2022. GOOD LUCK
December 2021
August 2021
June 2021
CORDIS EU publication
October 2020
New approach in DISTAL RADIUS TRAUMA surgery:
MINIMAL INVASIVE surgery repairing a fracture in hand using a special IMPLANT: compression screw with a special inlet made of MP-1™ polymer that allows TRACK WELDING of the K-Wires
These K-Wires hold the screw in place and prevent loosening of the implant, and at the same time allow free movement of the hand in all directions.
https://www.dropbox.com/s/h1gxqscdpr2vf7f/The%20Screw%20Project.mp4?dl=0
MMATECH is proud to announce that our paper was excepted to be presented in the Biomedical Engineering 2020 meeting – ISBME 2020 Annual Meeting in Haifa, Israel, 25 February, 2020.
PAPER TITLE: Game Changing Trauma Implants Made of MP-1™
AUTHORS: Alisa Buchman; Simha Sibony; Amir Oron
ABSTRACT:
MMATECH Ltd. introduced into the medical device market the game changing material MP-1™ of the polyimide family. Following a comprehensive pre-clinical research, which included biological, chemical, mechanical and physical tests with excellent results, the first articulating implant, a hip acetabular liner, was clinically implanted. The pre-clinical results showed excellent biocompatibility, high durability and safety. More than 110 Acetabular liner are already implanted with 2-15 years FU, as part of THR clinical study with excellent results. A new family of implants was developed for trauma injuries funded by the EU Horizon 2020 MP-ORIF project. Orthopedic fractures are a common daily acute health issue. A significant increase of bone fracture is expected in the coming years due to aging population, more active lifestyle, falling, and road and sport injuries. Fractured bone injuries are normally treated using various fixation implants (nails and plates) made of metal or composite materials. The use of metals in orthopedics involves increasing concern of developing pre-cancerous tumors in tissues and hyper-sensitivity reactions to metals in implant devices. The new MP-1™ trauma implants have the advantage of being a non-metal device which is easier and quicker to implant and safer to use. Three kinds of trauma devices were developed – a proximal Humerus nail, a proximal plate and a distal radius screw. All three devices were pre-clinically tested and clinically implanted in animals. Histology results showed excellent biocompatibility with growth of new bone around the implant within 6 weeks.
Entrepreneur Week in the Technion, Haifa, Israel
https://www.facebook.com/Technionalumni/photos/rpp.149323251887185/1495693907250106/?type=3&theater
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MMATECH is proudly located at the EU winning SME companies in the World
NEW ARTICLE
A new article was published in a peer-reviewed Journal in June 2019:
“MP-1™ Polyimide for Medical Devices: 1. Pre Clinical Studies”, P. J. Burn, A.
Buchman, S. Sibony, A. Oron, American J. of Biomedical and Life Sciences, 7 (3), June 2019, P. 42-51.
Abstract:
Due to constant increase in human life expectancy, more people require primary and revision total hip replacement surgeries, costing billions of US$ per year. Currently used ceramic on X-linked Polyethylene appears to be the best choice by default, but it still wears. The wear particles generated, are the major cause of osteolysis and joint failure. During 2011-14, leading orthopedic companies suffered global recalls of their Metal on Metal (MoM) hip systems resulting in thousands of revision surgeries. The search continues for new and more durable materials bearing materials. Developments in medical technology have increased the demand for advanced materials due to aging population, advanced medical procedures and contagious diseases. Metals and ceramics are prevalent in the medical industry. However, the unique properties of polymeric materials exhibit potential as better replacements for conventional materials. MMATECH Ltd. has developed a new articulation liner made of a revolutionary material of the Polyimide family, MP-1™, a spin-off of the Aerospace industry. MP-1™ has proved to be biocompatible, heat-resistant, highly crosslinked, combining unusual strength, toughness, self-lubrication, excellent friction and wear durability, as well as resistance to fatigue, creep, impacts and chemicals. These properties lead to longer life span and safer articulating implanted components. MMATECH received the CE and ISO certificates for its MP-1™ Acetabular liner of hip implant based on a pilot clinical study conducted in New Zealand with excellent 13y follow-up results. Ethical Committee approval was granted for a clinical study of 100 patients in New Zealand. The results of the first 82 surgeries follow-up demonstrated normal blood parameters, no osteolysis, and improved quality of life. The performance of MP-1™ even at 13 years is very promising and is now being applied to younger patients (~ 40 Y old) in view of the retrieval data. Part 1 of this research will summarize the pre-clinical studies while Part 2 will deal with the clinical studies.
link for the article: http://www.sciencepublishinggroup.com/journal/paperinfo?journalid=655&doi=10.11648/j.ajbls.20190703.11
MP-ORIF Annual Report
https://cordis.europa.eu/project/rcn/204298/reporting/en
MMATECH Ltd. RECEIVED AMAR CERTIFICATE
MMATECH Ltd. is happy to announce that the company received a Certificate of Registration in the Medical Equipment Registry (AMAR) from the Israeli Ministry of Health, Medical Technology Information and Research Division, on 10 October 2018, No. 31734. The certificate includes the use of acetabular liners made of MP-1™ for total hip arthroplasty implants.
MMATECH Ltd. Was invited to present a lecture at the
Life Sciences Baltics LSB2018 in Vilnius Lithuania
LSB is the only international forum in the Baltics for world-class biotechnology, pharmaceutical and medical devices experts from all around the world LSB brought together scientists of the brightest
minds in the field, speakers that includes researchers of top notch universities and institutes and experts from recognized life sciences hubs in the world.
Our lecture:
Orthopaedic Polymer MP-1™ application for 3D printing (invited lecture) was included in the session:”3D printing in medicine”in LSB2018 program, one of the warmest topics in science today.
The lecture was based on mutual work with Ortho-Baltic.
CEO Simha sibony and CTO Alisa Buchman
CTO Alisa Buchman gives a lecture
(מפרק מהחלל: הצצה לעולם המורכב של ניתוחי מפרק הירך (וידאו
איך הפך חומר שפותח על ידי מדענים ישראלים בעבור נאס”א לתקוותם של מושתלי מפרק ירך? איך מנתחים את הירך בלי לחתוך את השרירים? ומה הקשר בין המרכז הרפואי רמב”ם למרכזים רפואיים בניו זילנד? הצצה לעולם המורכב של ניתוחי מפרק הירך
13.3.18 13:52 כל בו
מאת: נעמי כהן, תוכן מקודם
בגיל 48 חשה ר’ מיוקנעם עילית שנמצא הפתרון לייסוריה. כתוצאה ממחלה שגרמה לה לנמק בראש עצם הירך היא סבלה מכאבים עזים וממגבלות קשות בתנועות יומיומיות פשוטות כמו הליכה, עליה וירידה במדרגות, ישיבה או קימה ובעצם כל פעולה שהצריכה כיפוף של הירך.
בירכה של ר’ הושתל מיסב חדשני העשוי מחומר פולימרי, שפותח על ידי המדענית הישראלית, ד”ר עליזה בוכמן, בעבור סוכנות החלל האמריקאית נאס”א, ויועד במקור עבור מיסבים למנועי סילון. תכונותיו העיקריות של החומר, ששמו המדעי הוא ™MP1: סיכוך עצמי, עמידות בפני חום גבוה, שחיקה אפסית, חוזק גבוה ומשקל קל. כל אלו הפכו אותו לאטרקטיבי גם לרופאים אורתופדים שבקשו להסב את החומר לניתוחי מפרקים.
מענה ניתוחי
מפרק הירך בנוי כמעין ראש כדורי, היושב בתוך גומחה קעורה. סביבו יש רצועות ושרירים השומרים על יציבותו ומסייעים לו בפעילותו. ראש עצם הירך מצופה בסחוס מפרקי המונע חיכוך, משמש כבולם זעזועים ומאפשר תנועה חלקה ללא כאבים. במקרים בהם נהרס הסחוס, כתוצאה מדלקת פרקים ניוונית או חבלה, נוצר חיכוך בין עצמות האיזור, מה שגורם לשחיקת מפרק הירך.
אילו אפשרויות טיפוליות קיימות היום לטיפול במחלה?
“אין תשובה אחת שתתאים לכל המטופלים”, מסביר ד”ר דניאל לוין, מנהל שירות ניתוחי מפרקים בקריה הרפואית רמב”ם ומומחה בניתוחי מפרק ירך, “התשובה תלויה בהיקף הבעיה, בצרכים המיוחדים של כל מטופל, גילו, עיסוקו, מחלות הרקע שלו וכו’. ברוב המקרים הטיפול הניתוחי נותן מענה יעיל ומוצלח יותר מטיפולים שמרניים כמו תרופות נוגדות דלקת, פיזיותרפיה והזרקות מסוגים שונים לתוך המפרק החולה. הטיפול השמרני אמנם מסייע בשיכוך זמני של הכאב ובהקלה זמנית של ההגבלה בתנועה, אך אין בו כדי לבלום את ההרס, לרפא את הסחוס או להקל על הכאב לאורך זמן”.
כ-4,000 ניתוחים להחלפת מפרק ירך מתבצעים מדי שנה בישראל. הסיבה הנפוצה ביותר לניתוח היא שחיקתה סחוסים, אוסטאוארטריטיס. כ-80% מהאוכלוסייה יסבלו משחיקה מסוימת בסחוס המפרק עד גיל 65, אך בין המטופלים שיעברו את הניתוח ניתן למצוא גם צעירים יותר הסובלים ממחלה מולדת, דלקת כרונית או שבר.
צפו: על העולם המורכב של ניתוחי מפרק הירך
הגישה הקדמית
יש גישות שונות לניתוח החלפת מפרק ירך. במערך האורתופדי בקריה הרפואית רמב”ם, תחת ניהולו של פרופ’ דורון נורמן, שמים דגש על ‘הגישה הקדמית’. לפי שיטה זאת ההליך הכירורגי מתבצע בחלק הקדמי של הירך. הניתוח מתבצע על גבי שולחן רגיל או שולחן מיוחד המיועד לטיפול בשיטה זאת כשהמטופל שוכב על גבו. “הגישה הקדמית מבטיחה שהמנתח יגיע למפרק בין השרירים ללא חיתוכם”, מסביר ד”ר לוין, “מה שמאפשר אשפוז קצר יותר, חתך קטן יותר, כאב מזערי , החלמה ושיקום מהירים יותר”.
כיצד מתבצע ההליך הניתוחי?
“מפרק ירך תקין נראה כעלי וכמכתש כאשר קצה העצם הירך הכדורית נכנסת לתוכו. במהלך הניתוח מבוצעת כריתה של המפרק החולה והחלפתו במפרק מלאכותי, העשוי ממתכות שונות, לרוב מטיטניום. בחלקו החיצוני של המפרק המלאכותי יש נקבוביות שתפקידן להיצמד לעצם, ולעודד אותה לצמוח לתוכו ולהפוך, בסופו של דבר, לחלק בלתי נפרד ממנה.
המפרק המלאכותי מורכב משלושה חלקים הפועלים בהתאמה מושלמת להשגת תפקוד מיטבי: עצם ירך (Stem ), ראש (Head ) ושקע האגן (Socket) . הראש מחבר בין עצם הירך לשקע שבאגן. כשבנקודת החיבור “תתלבש” על שקע האגן (Socket) מעין קערית, העשויה מחומר בעל מקדם חיכוך נמוך כדי לאפשר תנועתיות קלה יותר ושחיקה קטנה יותר של המפרק המלאכותי.
לרוב הקערית עשויה מאחד משלושת החומרים הבאים: פוליאתילן (החומר הנפוץ ביותר), מתכת או חומר קרמי. רמב”ם הוא המרכז הרפואי הראשון בישראל שהכניס את הMP1™ , החומר שפותח בנאס”א, לשימוש ניסיוני. שלושה מטופלים עברו עד היום ניתוח החלפת מפרק ירך עם החומר הזה. כשיסתיים השלב הניסיוני צפויים חולים נוספים להיכנס למעגל המטופלים ב. MP1™
בניו זילנד נעשה לראשונה שימוש בחומר החדש בניתוחי מפרק ירך לפני 12 שנה. מאז בוצעו שם בהצלחה כ- 80 ניתוחים כאלה, וככל שעובר הזמן מתברר כי עמידות השתל מהחומר החדש מצוינת. “כל השתלים עוברים שחיקה”, מסביר ד”ר לוין, “לאחר כ- 15 עד 20 שנה חלק מהמטופלים יאלצו לעבור ניתוחים חוזרים כדי להחליף את השתל בגלל התרופפות וסדקים. אנו מצפים שהחומר החדש יהיה עמיד לטווח ארוך יותר ויאפשר למטופלים איכות חיים טובה יותר ללא צורך בניתוחים חוזרים”.
Israeli space age material used in pioneering hip, knee replacement
Haifa’s Rambam hospital utilizes polymer developed by Nahariya start-up for NASA to replace bone tip in orthopedic surgery
By TOI STAFF Times of Israel, 10 December 2017, 8:03 pm.
https://www.timesofisrael.com/israeli-space-age-material-used-in-pioneering-hip-knee-replacement/
Dr. Daniel Levine performs innovative hip replacement surgery at Haifa’s Rambam hospital on December
10, 2017. (Piotr Felter)
As part of a pioneering new treatment, Haifa’s Rambam Medical Center used a material developed in Israel for NASA’s space program in orthopedic surgery, the hospital announced Sunday.
The advanced polymeric material is, according to the developer, “self-shielding, has high heat resistance, zero wear, high strength and light weight, all of which make it ideal for replacing worn joints,” reducing the likelihood of further operations as was the case when using materials that could crack over time.
The material, known as MP-1™, was originally developed by Alisa Buchman for the Nahariya-based start-up company M.M.A Tech, in collaboration with Rob Bryant of Virginia, US. It was intended to be used as a substitute for steel in the space industry, but the medical world also quickly realized its potential benefit.
The bearing made of the new material used in an operation in Haifa’s Rambam hospital on December 10, 2017. (Piotr Felter)
The first operation on humans using the new material was performed 12 years ago in New Zealand as part of a clinical trial. Three months ago Dr. Daniel Levine, Rambam’s joint service manager and specialist in hip replacement surgery, used MP1 in a hip replacement for a woman in her 60s. Recently it was also used as part of a knee replacement surgery on a 48-year-old woman from Yokne’am Illit.
“The goal is to give our patients the best treatment,” Levine said. “There is a development here that is still in the experimental stage, but on the face of it, it has properties that can give better results than existing materials.”
He explained that other materials used currently wear out quickly, requiring multiple surgeries.
“One of the problems with existing implants is wear and tear. Over time patients will have to undergo repeat surgery and replace the implant due to loosening and cracking,” he said. “The expectation of the new material is long-term durability and the possibility for patients to live with a better quality of life.”
Buchman was proud of the success of her discovery. “Our first recipient has been with the joint for 12 years without pain, and we are certainly encouraged by the results of the additional surgeries,” she said.
Due to the success of this new material, Buchman’s company received a research grant of €1.5 million ($1.8 million) to continue its development.
Interview with Alisa Buchman the CTO of MMA Tech Ltd.
First appearance on local TV channel 2
MMA Tech performed its first Total Hip Replacement implant in Israel !
6.9.2017
MMA Tech performed its first Total Hip Replacement implant
in the 2nd Medical Center in Israel (the 1st one being in New Zealand).
The surgery was successfully performed in Rambam Hospital by Prof. Daniel Levine
on a 58 years old patient who was released home after 4 days.
Rambam Haifa hospital tests first Liner implant of MP-1™ for Total HIP Replacement
A woman patient who broke her hip passed successfully a hip implant with a new material invented by an Israeli startup company MMATech.
A 58-year old woman has become the first recipient of an Israeli-developed implant to treat hip problems – a common condition for which there is no effective long-term solution (until now). The surgery was performed on September 6th at Rambam Health Care Campus, a medical center in Haifa, by orthopedic surgeon Prof. Daniel Levine.
The THR implant, includes 2 static parts – a stem and a cup and two dynamic rotating parts – a liner and a femoral ball, which usually wear within 10-15 years, resulting in the need for revision surgery. MMATech, an Israeli startup company in Nahariya, has developed a new Superior high performance plastic material which is self-lubricating and does not wear, creep nor fatigue. The tough new device is implanted as a replacement of the hip joint and can provide free motion for at least 25-30 years without failure. Therefore enabling surgeries in young people.
MP-1™ liner was implanted with 100% success in 74 patients in New Zealand for up-to 12 years in the body with no failure. Some patients were as young as 40 years old. The liner accepted CE and ISO and a Master File is registered at the FDA.
The patient was released from the hospital moving freely with no pain after 4 days.
The Israel Ministry of Health has authorized up to 15 clinical trials at Rambam center to test the efficacy of the new implant. Hearing of the success, Prof. Nimrod Rosen, head of orthopedic department of Haemek Hospital in Afula, intends to join too and is interested in implanting 50 more MP-1™ liners.
The potential market for the device is huge. It is estimated that more than 25 million people worldwide suffer from hip problems due to arthritis (aging), car accidents, army injuries and fall, conditions in which the person suffers from unbearable pain and limping.
Solutions implemented today include metal implants (causing metalosis), polyethylene (dimensional changes and wear with time) or ceramics (brittle) are less durable than MP-1™.
MMATech uses MP-1™ in several other applications such as dental implants, spine fusion cages, and trauma nails and screws (won a grant from Horizon 2020 “MP-ORIF”).
The MP-1™ technology originates from aerospace application and was developed for medical device applications by Alisa Buchman and Simha Sibony.
First THR implant in Israel with MP-1™ liner
Prof. Daniele Levine of Rambam Medical Center explains the benefit of MMA Tech’s MP-1™ revolutionary material.
M.M.A.TECH Wins Substantial Horizon 2020 Grant
Haifa, March 7, 2017 – MMATECH Limited is delighted to announce that the
company has secured a substantial Horizon 2020 grant of EUR1.6 million from the
European Commission.
Certificate delivered by the European Commission as the
institution managing Horizon 2020, the EU Framework Programme
for Research and Innovation 2014-2020.
KOM AGENDA
Date: August 29th, 2017
Location: Colony Hotel, Haifa, Israel
Project Coordinator: MMA Tech.
AUSTRALIAN ORTHOPEDIC ASSOCIATION |
5.9.2016
76th Annual Scientiefic Meeting (combined with New Zealand)
MMATech were presenented “The Life ScienceBaltic” conference held in Vilna,
Lithuania | 5.10.2016
The lecture to be presented: MP1TM, Clinical trial results of total hip replacement